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Thank you Experts for your feedback (Ron I'm still trying to get to your info!) I didn't want to mention any names when I sent the message out originally, but am please with your feedbacks so far. Further clarification: Greg/Q: if your Dad is doing so poorly I'd try another Dr. CARI/A: It's not that he's doing poorly - I just believe that this is one of the battles that PWP must face. Unfortunately he doesn't have anyone physically around him to observe him / keep the much needed daily journal / etc. So, I do what I can with the info I get or while visiting my parents. We're in pretty good shape as far as taking the meds so that his "off" periods are minimized as much as possible. Plus, stress play so much a part of his problems that it's difficult even when the meds are correct! GREG/Q: The med mix he's taking sounds bizarre to me. What good can 1/4 tab of sinemet really do? CARI/A: Actually, 1/4 chewed/crushed or whatever supplies a much needed boost when needed - it has "some" worth! GREG/C: Sinemet CR is not suppose to be broken according to manufacturer. CARI/Q: I know, and I saw Kathryn's response as well about the scoring - which is why we're considering that smaller script of CR - GREG/C: I just read an article by Dr. Iacino in CA which stated the standard gauge for sinemet is about 1- 25/100 tablet per year of PD. CARI/A: Do you mean that he would be taking fifteen 25/100 per day? I don't think anyone is using that "formula" - but I know it's theory. . . Believe me - your lay opinion is valuable to us all! On Mon, 19 Jun 2000 16:04:33 EDT Cari Barrett <[log in to unmask]> writes: 1. we are always trying to balance out the dyskinesia with the Tasmar/Sinemet 25-100 IVAN/C: Cari, You can try cutting the Tasmar down to 50 m per dose, by splitting the 100 mg tablets with a pill-cutter. . . CARI/A: No, we haven't tried that yet - but I'll check with his doctor and see what he thinks, especially for the 11a dose > > 2. he has an extremely hard time (usually) getting up in the > morning, GREG/Q: ... have you tried giving your dad Sinemet or SInemet CR after 5 PM?? His body will require some dopamine throughout the night. I am pretty sure that this will reduce his morning difficulties. CARI/A: yes, we've tried that and it didn't do anything for the morning problem - it did, however, assist in adventurous and sometimes physical dreams at night! Assuming that the CR has the three hour lifespan - your schedule makes sense - especially the 3:45a dose - however I can't see my Mom getting up to give it to him. And I don't know if he could do it himself if he set his alarm - but we might try it - thanks - Ivan QUESTION TO ALL: how many of you take doses throughout the night? Just curious to see how it affects YOUR morning abilities. ----- Original Message (partial)----- From: "Cari Barrett" <[log in to unmask]> Sent: Monday, June 19, 2000 4:04 PM > In the constant quest of finding the best combination of sinemet, agonists > and timing - I don't understand how so many are taking full doses of Sinemet > 25-100 and CR 50-200 repeatedly during the day - > while my dad, after 15 years > (AND, remember this is the guy whose doctor said he's at the "End"...) > > is only taking - > Sinemet 25-100 > 1/4 6a, 9a, 2p,5p > > CR 50-200 > 1/2 6a > 1/4 9a, 2p, 5p > > Permax 1mg > 1 6a, 11a, 2p > Tasmar 100 mg > 1 6a, 11a > > 1. we are always trying to balance out the dyskinesia with the > Tasmar/Sinemet 25-100 > > 2. he has an extremely hard time (usually) getting up in the morning, so > chews up his 6a 1/4 Sinemet 25-100 > > 3. We are considering the CR 25-100 now that you all told me exists, but > haven't done it yet - as we realize that 1/2-ing and 1/4-ing the CR is insane > - but if he takes 1/2 CR at 9a for several days - he's totally hyper and out of > control until the evening - > > if he takes 1/4 CR at 9a for several days (during our "trial periods") he can > hardly get out of bed at all, has little or no energy - Cari daughter of Dempsey-PWP (71/16+) & Jo Ann-CGiver