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Ivan M Suzman wrote: > Comtan is described as unable to > cross the blood-brain barrier. In some way, > does this affect what you have described? I don't think so. Both Comtan and Tasmar are supposed to inhibit COMT mainly in the peripheral nervous system, but both are observed to do so as well in the central nervous system. Cheers, Joe -- J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks, CA 91403-5013