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it is amazing that we have never met before. With some very slight variation, you are describing my drug history, i have been taking sinemet for 17 years. i am extremely sensitive to it - i take the 25/100CR which i break in half - one half every 2 hours or so - usually closer to 90 minutes. but, as you describe, sometimes for no apparent reason, that is too much, other times not enuff. Yesterday the whole day i struggeld to try and get moving, but my medication just wouldnt kick in. finally at about 11pm i couldnt stand the heaviness and the lethargy any more - besides, i had to start packing to go to the forum - and i became so dyskinetic, i could hardly think straight. Didnt get to sleep til 3.30 and since i took my first dose at 7.30 and another at 10.30., the dyskinesia has been getting wilder and wailder, I also take comtan and requip. at first the comtan seemed like an answer to a prayer - i cut downm my need for sinemet to about a third, but the need has been gradually creeping up again resulting in days like yesterday and today. i was taking anmantadine til about 4 monnths ago, but my legs swelled up so badly, i had to stop. WIth amantadine however, i was doing fine - very little dyskinesia, no dystonia, and almmost no tachykinesia - all three are now big problems . have you considered surgery? hilary blue 51,33,24 > Hi, > I can't really remember how much sinemet I started on 16 years ago ( > not 17) but the dosage has gradually increased over the years. I'm > now taking 1200-1600 mg of sinemet a day. The dosage varies because I > try not to take anymore than I have to but that changes daily > depending on my sleeping, eating, and other factors of daily life. I > generally take one 25/100 about every 1 hour and 20 minutes. > Occasionally, I take spells where I can go 1 1/2 hours and then again > I may have to take them every hour. I set a timer to help me remember > because the time goes so quickly and if I miss a dose and go off, if > takes a stronger dose and a lot longer to get back on. I have taken > as much as 2200 mg a day for several weeks at a time. Then something, > we have no idea what, changes and I can cut back again. > > In addition to the sinemet I take 3- 200 mg tasmar and 4 -100 mg > symmetrel. I have tried all the agonists and cannot tolerate them. > When taking them, even though I can cut back on the amount of sinemet > the dyskinesias are unbearable. I have also used apomorphine with > limited success. I also take 1-15 mg restoril and 1/2-25 mg clozaril > to help me sleep. They help, but I still don't sleep well. > > Dwayne 55/16 >