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"Mario A. Gonzalez" wrote: > Do NOT take MAO Inhibitors when taking Comtan (entacapone); serious > interactions can occur. There may be other drug interactions; consult your > doctor for more information. The info I have says in effect, there are two kinds of MAO, A and B. MAO-A is one of the two main defenses against overproduced epinephrine, and COMT is the other. Therefore combining an MAO-A inhibitor (e.g., Parnate) with a COMT inhibitor (e.g., Comtan) defeats both safeguards and may be risky. However an inhibitor of MAO-B (e.g., Eldepryl), supposedly because MAO-B acts only within the brain, isn't in that category and therefore is safe to combine with a COMT inhibitor such as Tasmar or Comtan. See my previously posted note "Inhibiting The Inhibitors". Cheers, Joe Joe -- J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks, CA 91403-5013