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Hi Joe Comtan is described as unable to cross the blood-brain barrier. In some way, does this affect what you have described? I think Mario should know that the Demerol- Eldepryl cross-reaction is the dangerous one -it speeds the heart, I am told. Thanks, Ivan 50/39/36 On Thu, 22 Jun 2000 20:51:29 -0700 "J. R. Bruman" <[log in to unmask]> writes: > "Mario A. Gonzalez" wrote: > > Do NOT take MAO Inhibitors when taking Comtan (entacapone); > serious > > interactions can occur. (SNIPPED)