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Phil Tompkins wrote: ... taking my pills was getting complicated. This was when dyskinesia was becoming bothersome and my responses (or occasional lack thereof) to medicines began to vary from one dose to the next and to depend on such things as what I ate and when I ate it and how much. > For a time I tried not taking the next dose until the previous dose wore off, to see how long a dose would last. > Not only was all this very useful in adjusting dosage levels and times, but I learned a few things, such as: > > the interval from dose time to time "off" increased throughout the day, and > the interval from dose time to time "off" at a given time of way was more constant than the interval from dose time to time "on". This illustrates what I (and many others) have said for a long time: For PWP at the "fluctuating" stage, a rigid timetable for Sinemet will not do (although it may be ok for other PD drugs) because the onset, severity, and duration of "wearing off" depends on so many variables of daily living activity. You need to maintain both a constant daily intake and a timely response to the unpredictable need or lack thereof. The objective of this is not to retard PD's relentless progression (it won't) but to maintain the best possible quality of life under the circumstances. Cheers, Joe -- J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks, CA 91403-5013