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At 12:34 PM -0500 7/2/00, David Rehm wrote: >We finally had our first appointment with Dr. Rao - movement disorder >specialist - in New Orleans last Thursday. After talking with us and >examining her, he has made an initial assesment that she has Lewy Body >Disease. He immediately told us to stop taking Permax and Celebrex and >he has increased her dosage of Sinemet from 2 CR 25/100 to 4 CR 25/100, >leaving it up to my dad and I to find a correct dosage and timing schedule. i am not a medical professional. but have studied what seems to be optimal as well as researched the data. two suggestions: read: http://www.ridgecrest.ca.us/~rfvetter/levodopa.pdf that you can download into Adobe Acrobat. give your mother half a 25/100 CR upon arising or while awake in bed in the morning. then give half a tablet every 2 hours unless she is sleeping or going to bed before 2 more hours. if the above does not seem satisfactory, try the regular (not CR) tablets 25/100 at the same schedule (but have meals no sooner after a dose than 15 minutes; and, do not take a dose less than 45 minutes after a meal.) Do take a single graham cracker or peppermint or piece of fruit or couple of dried fruit such as apricot or prune. the regular is dissolved easier and suffices at 2-hour intervals for most of us. it gets dissolved 100 % versus ~77 % for the CR. does she sleep through the night? did she? good luck. ron -- Ron Vetter 1936, '84 PD dz mailto:[log in to unmask] http://www.ridgecrest.ca.us/~rfvetter