Connie, There have been several messages recently about patients that have been told to take 1 Comtan per day. I believe they have misinformed neurologists. I believe the correct dosing for Comtan is to take Comtan with EACH dose of Sinemet --- unlike Tasmar. Your results would indicate, to me, that the Comtan is apparently working for Jack because you get good results in the morning. If you are getting a response to the Comtan you would expect poor results later in the day when you are not taking it. It sounds from your description that Jack is one of those people who gets a favorable response to Comtan but is not taking it as intended. In my brother's case Comtan was totally useless ---- no favorable response at all ---- only complications like constipation. It is also much more expensive to use than Tasmar. Paul ----- Original Message ----- From: Constance Tate <[log in to unmask]> To: <[log in to unmask]> Sent: Wednesday, July 05, 2000 8:02 PM Subject: comtan??? dear list i am rather upset about jack's neuro and would like feed back on this. we saw neuro apr. and he started jack on comtan 200 units with first sinemet 50/200 cr and call back in 2 weeks to see how it worked. it made a big difference early in morning. jack's voice became stronger and he seems to feel well until midafternoon. he had been taking 25/100 sinemet same as pre comtan and 8 pm 50/200 sinemet. as the afternoon progresses he is slower and tired. when we called 2 weeks ago and told nurse he was slower she-not the doctor called back a few days later to tell jack to add 50/200cr to 50/100 sinemet in afternoon and call back again in 2 weeks. well i told our primary doctor about it and she said she would speak to neuro---result today again nurse phoned and said neuro wants jak to increase dose of sinemet again---and call back in 2 weeks.maybe at that time neuro may want to see how jack is doing. well it seems that all i have read is comtam is to help reduce sinemet not increase it. has this happened to anyone else? he has not icreased the comtan so all jack is taking is the one in morning i am puzzled with this and hope you can advise whether this is usual or not. perplexed connie