Hi murray; I've just started comtan last week @ 6/25/2000, 20 mg x 3 per day. I'm taking this because of painful dystonia events i have each day. my other meds are sinemet CR 50/200, 2.50mg requip. Do you have the same problem with leg and arm cramps? I still have some minor to moderate cramping but its a heck of a lot more manageable. I'd like to hear from anybody who is having these symtoms. Thanks, BIll Mason