>Further to some recent messages that dealt with the dosing
>regime for Comtan (once a day v. with every dose of
>Sinemet), consider the following:
>
>"The plasma elimination half-life of [entacapone] is 1.5 to
>3.5 hours." -- Statement quoted from RIVEST J et al. COMT
>inhibitors in Parkinson's disease. Can J Neurol Sci 1999;
>Suppl 2, Aug 1999: S34-S38 -- apparently based on NUTT JG et
>al. in Neurology 1994; 44:913-919.
>
>
>Similar information comes from KERANEN T et al [in Eur J
>Clin Pharmacol 1994;46(2):151-7], as follows:
>
>"... an open study in 12 healthy young male volunteers ...
>Entacapone was rapidly eliminated by metabolism with a
>half-life of 0.27-0.30 h after oral doses of 5 to 50 mg.
>After doses from 100 to 800 mg the disposition was best
>described by two phases with a t1/2 alpha of 0.27-0.37 h and
>t1/2 beta of 1.59-3.44 h."
>
>To me this suggests that, in general, a person taking Comtan
>once daily would have the benefit of the drug for part - but
>not all - of the day.
>
>Ben Winter
>Victoria BC Canada
>
>Dear Ben,
I'm from Port Alberni and have been looking for more information on
Comtan. Would appreciate pensonal contact. My E'mail address is
<[log in to unmask]> phone # 250 724 4203. Thankyou Hank Dyck.
