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> Mary Ann, > Did you reduce the Sinemet when you got a positive reaction from > the Comtan? No. > > Dyskinetias are caused by too much Sinemet activity. If the > Comtan is making the Sinemet more active you need to take less > Sinemet. My husband is taking 1/2 tab of Sinemet 25/100. You can't get much lower than that for a Sinemet dose. All his neuro is trying to do is to increase the 'on-time' of his Sinemet dose, since 1/2 tab doesn't last that long. My husband has *never* tolerated Sinemet well. Since his first dose, he has suffered from dyskinesia - and that was 20 years ago. We keep praying for a more effective med. Considering that he is on a cocktail of PD meds (Symmetral, Eldepryl, Miripex, Comptan, and Sinemet), there's not much more to add or subtract to maintain his function. ----- God bless Mary Ann