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Mary Ann, Has your husband tried !/2 of a Sinemet 25/100 CR instead of 1/2 of a Sinemet 25/100, in each dose? That might slow down the absorption of the L-dopa, and spread it over time. Also, could the frequency of Comtan cause dyskinesia? Comtan's half-life is longer than Sinemet's, so I question the Comtan with each Sinemet dose idea. I do NOT take Tasmar with every Sinemet dose, because Tasmar's half-life is MUCH longer than Sinemet's. And dyskinesia is avoided by doing this. Ivan :-) On Wed, 12 Jul 2000 09:03:01 -0400 Mary Ann Ryan <[log in to unmask]> writes: > > Mary Ann, > > Did you reduce the Sinemet when you got a positive reaction from > > the Comtan? > > No. > > > > Dyskinetias are caused by too much Sinemet activity. If the > > Comtan is making the Sinemet more active you need to take less > > Sinemet. > > My husband is taking 1/2 tab of Sinemet 25/100. You can't get much > lower > than that for a Sinemet dose. All his neuro is trying to do is to > increase > the 'on-time' of his Sinemet dose, since 1/2 tab doesn't last that > long. > > My husband has *never* tolerated Sinemet well. Since his first > dose, he has > suffered from dyskinesia - and that was 20 years ago. We keep > praying for a > more effective med. Considering that he is on a cocktail of PD meds > (Symmetral, Eldepryl, Miripex, Comptan, and Sinemet), there's not > much more > to add or subtract to maintain his function. > ----- > God bless > Mary Ann ^^^^^^ WARM GREETINGS FROM ^^^^^^^^^^^^ :-) Ivan Suzman 50/39/36 [log in to unmask] :-) Portland, Maine land of lighthouses HOT (for Maine) and sunny 87 deg. F :-) ********************************************************************