> Has your husband tried !/2 of a Sinemet 25/100 CR > instead of 1/2 of a Sinemet 25/100, in each dose? He's tried 1/2 of Sinemet CR - but there doesn't seem to be much difference in his functioning ability or dyskinesia on that med. > > Also, could the frequency of Comtan cause dyskinesia? > Comtan's half-life is longer than Sinemet's, > so I question the Comtan with each Sinemet dose idea. He only takes 1 Comtan a day - during the roughest part of his day, which happens to be in the afternoon. So far he's noticed that his functioning ability is extended by no more than 1/2 hour - but he's grateful for that. His dyskinesia remains relatively the same - and seems to be dependent upon how much Sinemet he's taken over the course of the day. The less Sinemet, the less dyskinesia - and the less functional ability, of course. This is 'razors-edge' medical management, and neither of us likes it. But....ya gotta do what ya gotta do. ----- Thanks for your concern, Ivan Mary Ann