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It must be really frustrating to be given the runaround for so long. From reading other contributions to the list, you aren't alone. It seems to me that some physicians are more concerned with fitting us into neat diagnostic boxes rather than accepting that nature can be pretty untidy. Just because you don't have all the classic symptoms of PD, you can't have PD,same for AD. But why shouldn't you have some of this and a little of that? Nature doesn't know that you need to be labelled, lined up, photographed and boxed! As to your questions, pass on 1, don't know how effective the drugs will be at such levels. 2. From what I read and hear, dyskinesia (she's a beaut word alright)is the result of too much dopamine compared to your deficiency. If you have a chronic deficiency you should be able to soak up more dopamine before feeling unwanted side effects. If it does get unmanageable, you'll probably be put on a combination of levadopa with an agonist. 3. If these large doses cause nausea, taking them with food can help (that's the plus) but boosting the level of protein in your blood will reduce the effective transport of levadopa out of your gut, through the bloodstream and into the brain. So, if you have to eat, then low protein high carbohydrate meals are recommended for the active parts of your day. But you still need protein, (though probably less than you imagine), so save the proteins until late in the day when it won't matter if the medication is less effective. Ideally, you should accustomise yourself to taking the meds without food, then slow uptake isn't a problem. Hope this doesn't disagree widely with the many other opinions you are bound to get on this. Alf, Adelaide, Aust 50/<1/48