Hi Dianne, I have had pd for twenty years and when I was placed on Prozac my lead neurologist and I had a conversation of the benefits of Prozac. In my case the Prozac helped with the depression and also enhanced the effectiveness of the Sinemet to the point that I was actually able to decrease my daily dose of Sinemet. As you will be warned by many others each individual response is different. I hope this helps..... Good luck, Sandy Norris 40/28/20 "Faith is the daring of the soul to go farther than it can see."