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Levodopa drug holidays were a fad in the 1980's. Later work showed that theywere NOT beneficial or altered the course of the disease in any way, but did have the ppossibility of causing medical complications such as leg vein clot, pulmonary emboli, and "neuroleptic maligant-like syndrome." Although some patients did improve, the consensus was that the improvement was not due to the drug holiday itself but to the adjustment in medication which occurred after the drug holiday, and could be done without the danger of the drug holiday. There is not much recent literature which addresses or promotes drug holidays any more. Jorge Romero, MD ----- Original Message ----- From: "Michel Margosis" <[log in to unmask]> To: <[log in to unmask]> Sent: Sunday, July 30, 2000 4:29 PM Subject: Re: PD: Drug Holiday > Barba and I just talked about it last night as we were discussing her > therapy which includes a panoply of drugs. She has been reacting badly > (i.e., hallucinations and very vocal nightmares) to some of them and > it is difficult to attribute such and such reaction to any particular > drug. > Has the drug holiday become too risky or ineffective? > Michel > > "Marjorie L. Moorefield" wrote: > > > Does anyone do drug holidays anymore, or did > > they decide it was too hard on the patient? > > >