sorry last message sent before i finished i am trying to adjust jacks meds after neuro changed them and he got worse. talking to our local doctor i asked her if i could change some sinimet plain in place of sinemet cr as he seems wiped out for quite a while after taking cr. she said try substituting 2-25/100 in place of the sinemet 50/200 andsee how it works. right now his meds are 8am > 2- 25/100 sinemet 1- comtan 1- senna+ 12 noon 1- 50/200 cr sinemet 1- proscar 1- senna* 4pm 2- 25/100 sinemet 1- comtan 8 pm 1- 50/200 cr sinemet 2- 2 senna+ he seems to feel fine after 8 am dose and the 4 pm dose but is very slow after noon meds and in evening very sleepy. does it make sense to just have him replace the 2 50/200 cr doses with 2 25/100 as i did with the morning and 4 pm doses and stop all the 50/200 cr as they don't seem to do him any good? connie