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I appreciate your comments, but I have full confidence in Dr. Linda Sigmund who has been written up as one of the top 100 Drs. in the Washington DC area. At this stage I do believe that I should second guess this movement disorder specialist; the stakes are too high. I believe that this crisis was precipitated by one or both changes in the medication: (1) a change from regular Sinemet to CR, and (2) a change from Seroquel to Zyprexa; so we returned to pre-crisis conditions with significant reduction in the Sinemet and Permax. Again, thanks. Michel PS Perhaps I do not know how to get info from PIEN, I tried but got minimum results. John Cottingham wrote: > There is a medication that handles most of the untoward side-effects of PD medications. I don't know if your neuro has tried it or not but the drug is clozapine. Generally it will relieve the hallucinations while at the same time allowing higher dosages of Sinemet and its benefits. > > You can use the search engine on P-I-E-N-O to search for the word or words. > > http://parkinsons-information-exchange-network-online.com > > My prayers are with you both.