You're better off with Clozaril. My personal choice if/when
I need it. (Sorry- 3 words over.)
N. Carol(E)
--- "Marjorie L. Moorefield" <[log in to unmask]> wrote:
> Dear Nurse Carol,
> In 10 words of less, exactly what are
> you saying?
> Remember, I'm a librarian and a Witch,
> not a nurse.
> But to tell the truth, between my Husband
> and my Dog, I'd have been better off to have
> been a nurse.
>
> just me,
> Marjorie
>
>
>
> At 04:19 PM 10/02/2000 -0700, you wrote:
> >janet, this is becoming increasingly obvious in
> psychiatric
> >practice. The Atypicals like Olanzapine/Zyprexa and
> >Risperidone/Risperdal were promoted as being free of the
> >EPS(motor fluctuations like the Thorazine shuffle),
> >dystonic reactions, and tardive dyskinesias of the older
> >meds. This has not been entirely accurate. The only
> psych
> >med that actually improves (some say masks)these
> >troublesome side-effects is Clozapine/Clozaril. I run a
> >Clozaril Clinic and we are currently tracking 100% of
> our
> >patients using the
> >Abnormal Involuntary Movement Scale.
> > Carole 54/51/?45(I'm beginning to
> think
> > even younger)
> >
> >--- janet paterson <[log in to unmask]> wrote:
> > > Olanzapine and clozapine: comparative effects on
> motor
> > > function in
> > > hallucinating PD patients.
> > >
> > > OBJECTIVE: To compare olanzapine and clozapine for
> safety
> > > and efficacy
> > > measures of psychosis and motor function in patients
> with
> > > PD and chronic
> > > hallucinations.
> > >
> > > BACKGROUND: Hallucinations occur in approximately one
> > > third of patients
> > > with PD treated chronically with dopaminergic drugs.
> > >
> > > Although clozapine is known to be an effective
> > > antipsychotic agent that
> > > does not significantly exacerbate parkinsonism, its
> use
> > > requires frequent
> > > blood count assessment.
> > >
> > > Olanzapine is another novel antipsychotic that is not
> > > associated with blood
> > > dyscrasia, and if equally effective could become the
> > > preferred drug for
> > > treating hallucinations in subjects with PD.
> > >
> > > METHODS: A randomized, double-blind, parallel
> comparison
> > > of olanzapine and
> > > clozapine in patients with PD with chronic
> hallucinations
> > > was conducted.
> > >
> > > The primary outcome measure was the Scale for the
> > > Assessment of Positive
> > > Symptoms (SAPS) for psychotic symptoms.
> > >
> > > The Unified Parkinson's Disease Rating Scale (UPDRS)
> > > motor subscale was
> > > used as a secondary outcome measure and as a safety
> > > monitoring tool.
> > >
> > > RESULTS: After 15 patients had completed the study,
> > > safety stopping rules
> > > were invoked because of exacerbated parkinsonism in
> > > olanzapine-treated
> > > subjects.
> > >
> > > UPDRS motor impairment scores from baseline to study
> end
> > > significantly
> > > increased with olanzapine treatment, and change
> scores
> > > between the
> > > olanzapine and clozapine groups significantly
> differed.
> > >
> > > The primary clinical domains responsible for the
> motor
> > > decline were gait
> > > and bradykinesia.
> > >
> > > Even with a smaller patient number than originally
> > > anticipated, clozapine
> > > significantly improved hallucinations and overall
> > > behavioral assessment,
> > > whereas olanzapine had no effect.
> > >
> > > CONCLUSIONS: At the doses studied, olanzapine
> aggravates
> > > parkinsonism in
> > > comparison with clozapine and should not be regularly
> > > used in the
> > > management of hallucinations in patients with PD.
> > >
> > >
> > > PMID: 10993997, UI: 20451175
> > > Neurology 2000 Sep 26;55(6):789-94
> > > Goetz CG, Blasucci LM, Leurgans S, Pappert EJ
> > > Rush-Presbyterian-St. Luke's Medical Center, Chicago,
> IL;
> > > and San Marco
> > > Neurology
> > >
> > > janet paterson
> > > 53 now / 44 dx cd / 43 onset cd / 41 dx pd / 37 onset
> pd
> > > TEL: 613 256 8340 URL:
> http://www.geocities.com/janet313/
> > > EMAIL: [log in to unmask] SMAIL: PO Box 171 Almonte
> > > Ontario K0A 1A0 Canada
> >
> >
> >
> >__________________________________________________
> >Do You Yahoo!?
> >Yahoo! Photos - 35mm Quality Prints, Now Get 15 Free!
> >http://photos.yahoo.com/
__________________________________________________
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