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Joe.....thx for all the postings you do on the latest pd info....have learned a great deal from them without having to read the whole article unless I want to .....you bring into focus up to date items that I would not think to search for..... Joan Hartman > [Original Message] > From: J. R. Bruman <[log in to unmask]> > To: <[log in to unmask]> > Date: 10/5/00 9:14:59 AM > Subject: CSR OCT 00 > > CURRENT SCIENCE REVIEWS By Joe Bruman October 2000 Page 1 of 3 > > Lane R:J Neur N'surg Psych 2000;69:289: > After 6 years of near-zero mention in professional literature > about PD, but ample discussion among patients, we now learn that > "chronic fatigue is a very common complication of... diseases > such as ... Parkinson's disease" (editorial comment on Chronic > Fatigue Syndrome paper, pp 302-307). Well, well. > > Schrag A et al:J Neur N'surg Psych 2000;69:308-312: > By questionnaire to subjects of a population-based study of PD > prevalence, authors found that the factors most commonly > affecting quality of life in PD are depression, postural > instability, and cognitive impairment. > > Soliveri P et al;J Neur N'surg Psych 2000;69:313-318: > They applied a battery of cognition tests and motor scales to > about 5 dozen patients having either PD, Striatonigral > Degeneration (SND), or Progressive Supranuclear Palsy (PSP), > on two occasions averaging 21 months apart, to detect and > compare rates of progression. > > Benke Th et al;J Neur N'surg Psych 2000;69:319-325: > A preliminary study in 53 PD patients of repetitive speech > phenomena, both hyperfluent and disfluent, in PD at different > stages of disease progression. > > Rettig G et al;J Neur N'surg Psych 2000;69:326-336: > In the largest long term followup to date, in 42 PD recipients > of unilateral pallidotomy, examined as long as one year after > surgery, cognitive impairment was minimal compared with the > robust improvements in motor function. > > Pal P et al;;J Neur N'surg Psych 2000;69:337-344: > In examination 3 years later of 15 unilateral pallidotomy > recipients with PD, control of dyskinesias and tremor persisted, > but all other early benefits were lost, and activities of daily > living continued to worsen. > > Haberler C et al;Ann Neur 2000;48:372-376: > Postmortem study of 8 PD patients who had deep brain stimulation > (DBS) for as long as 70 months showed no damage to adjacent tissue > by chronic DBS. > > Lancet, 26 August 2000, 693(editorial): > Laboratory study of stem cells offers the most promising pathway > to a means of preventing or curing PD, but some people think all > or part of such study is immoral, and have organized opposition. > The status of this ethical/scientific/political battle varies > widely among different nations, but Lancet thinks a recent UK > report on stem cells may hasten its resolution. > > CURRENT SCIENCE REVIEWS By Joe Bruman October 2000 Page 2 of 3 > > Lancet, 9 September 2000, 917(news item): > In a PET study of orthostatic hypotension, researchers found that > all the PD subjects studied had lost norepinephrine-producing > neurons in the heart. While it's known that PD affects peripheral > autonomic functions (notably bowel motion) controlled outside the > cns, this is (I think) the first positive evidence that a neuro- > transmitter other than dopamine is involved in PD. > > Onodera H et al;Lancet, 26 August 2000, 739-740: > In test of chemosensitivity to hypoxia in 25 PD patients and 11 > controls, even in early stages of PD the former had subnormal > hypoxic response accompanied by blunted perception of dyspnoea, > that might account for the unusual frequency of respiratory > failure in PD. > > Science News, 2 September 2000:148(news item): > Status in the U.S. of the stem cell controversy (see above). > > Pahapill P, Lozano A;Brain 2000;123:1767-1783: (review article) > In PD, significant loss of neurons in the pedunculopontine* > nucleus suggests that area as the source of akinesia and gait > disturbance in PD, which might be a promising site for potential > future therapy. *[The peduncle is a stalk which connects the > cerebellum to the midbrain at the pons. JB] > > Hadjikoutis S et al;Brain 2000;123:1863-1873: > Since the pharynx passage is common to both swallowing and > breathing, it's possible to aspirate material into the airway. > To avoid that, swallowing normally is followed by exhalation. > Patients having various neurological diseases may inhale, more > often than healthy subjects, after swallowing, but authors > couldn't find any association with the frequency of subsequent > choking or coughing episodes. > > Kulisevsky J et al;Mov Disord 2000;15:613-626: > They studied a group of new PD patients for up to 24 months to > compare the effects on cognition of levodopa versus pergolide > (Permax), but found no big difference. > > Leiguardia R et al;Mov Disord 2000;15:627-640: > Disruption of spatial organization and interjoint coordination > in Parkinson's disease, progressive supranuclear palsy, and > multiple system atrophy, study by computergraphic analysis. > > Homann C et al;Mov Disord 2000;15:641-647: > The Bradykinesia Akinesia Incoordination Test (BRAIN TEST), an > objective and user-friendly means to evaluate patients with > parkinsonism, by finger-tapping performance. > > Hauser R et al;Mov Disord 2000;15:658-663: > Evidently responding to reports (CSR JUL 99) of blackout-related > automobile accidents, they studied a lot of pramipexole (Mirapex) > users and came up with advice not to drive if sleepy. > > > CURRENT SCIENCE REVIEWS By Joe Bruman October 2000 Page 3 of 3 > > Shulman L et al; Mov Disord 2000;15:664-668: > An extensive chart study, to test the common opinion that > dopamine receptor agonists have too many bad side effects for use > in treating very elderly PD patients, showed that they were well > tolerated by nearly half of the subjects. > > Shiba M et al;Mov Disord 2000;15:669-677 > A records study of PD patients and controls suggests that anxiety > disorders are associated with PD, and may appear as long as 20 > years before PD's motor symptoms. > > Ondo W et al;Mov Disord 2000;15:678-682: > Open-label tests suggested that gabapentin (Neurontin) is helpful > against essential tremor (ET), but a multiple-dose, double-blind, > placebo-controlled trial failed to confirm that. > > Hurtado J et al;Mov Disord 2000;15:683-691: > Analysis of temporal correlation between tremor of different > muscles of the same and different limbs in 4 PD patients. > > Benamer H et al;Mov Disord 2000;15:692-698: > Correlation of PD severity and duration with striatal dopamine > uptake, as observed by Single-Photon-Emission Coomputed > Tomography (SPECT) using the marker 123I-FP. > > Maraganore D et al;Mov Disord 2000;15:714-719: > A case-control study of several mutant genes for possible > association with PD turned up the M3 allele of the liver- > detoxifying enzyme N-acetyltransferase 2 (NAT2) as a > likely prospect. > > > -- > J. R. Bruman (818) 789-3694 > 3527 Cody Road > Sherman Oaks, CA 91403-5013 --- Joan Hartman --- [log in to unmask] --- EarthLink: It's your Internet.