Hi Jeanne and Gordon: I really commiserate with you; I have had 17 years of a great variety of symptoms. none have been terribly painful but they have made me very uncomfortable much of the time. For a 3-4 year period I had cramps, mostly in the calves of my legs. They woke me about 5 am and persisted for about an hour ; until my medications took effect. My wife could relieve them with just lightly stroking the affected area. I have learned that massage can loosen up blood clots which is potentially lethal. One of my nurse daughters suggested flexing my leg so my toes point up rather than down. I can usually do this without calling my wife for help. I usually get very quick relief. I still have an occasional cramp, but is more manageable now. I may have had some help from Permax but never noticed a definite response to any thing we tried, Best Wishes, Bill Olson Now 80; dx at 63 From: "Jeannie Leroux" <[log in to unmask]> To: <[log in to unmask]> Sent: Wednesday, October 11, 2000 12:46 AM Subject: Leg Cramps > My husband, Gordon, is the PWP. He works pretty well through the day as > long as he keeps on his medicine schedule. However, at night he has a lot of > difficulty getting in and out of bed, using the bathroom, turning over, and > adjusting the covers. Many times I have to help him up, cover him up, or > turn him over. Do other people have difficulty at night, especially in bed? > I try to get him to spread his medicine so he has more during the night, but > he hates to give up the good part of the day by postponing his medicine. He > is on sinemet, mirapex, and selegeline. Also, lately he have been having > nightly leg cramps. Sometimes they are in the foot, calf, or high up by the > buttox in the thigh. It does help when I rub the area. Does anyone have any > ideas? > Jeannie Leroux > Everett, WA