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Hi Sandra... I'm Helen, new on the list. I was diagnosed six years ago with PD and started immediately on Sinemet 25/100. About a year and a half ago, because I had down time in the morning, I was changed to Sinemet CR 50/200, taking one three times a day. I am also taking Eldypril (1 tablet twice a day). The result was that in a month's time, I had started having dyskinesia. My Internist and my daughter (a nurse) both noticed the change in me. As it turned out I was overmedicated and was cut back to 1/2 tablet 3 times a day and am much improved. Our support group had a speaker from Barrows Neurological Center who told us that a CR can be broken in half and still have the full value of the tablet. I have been doing that for some time now. Tell your friend to check with her neuro about the severe dyskinesia she is having to make sure she isn't taking too much. I hope this helps. Helen On Wed, 11 Oct 2000 23:01:49 -0700 Sandra Norris <[log in to unmask]> writes: > Hello List Family, > > I have a friend with Pd that has suffered with dyskinesias off and > on since 8:00 am. I just got off the phone with her. She has had > only two non-dyskinetic hours today. Here are her stats...She has > been diagnosed for 4 years, symptomatic for 1 1/2 to 2 yrs before > dx. She is on Sinemet CR 50/200 . She takes 1/2 tablet to get her > started in the morning. The only other med she is on is Requip. > She takes the sinemet morning and early afternoon. But today she > has only had the morning 1/2 tablet...not sure about how much requip > she has had..maybe 2 doses..or 3. > > My question is...Is it recommended to cut a CR tablet in half? > Would this not effect the time-release capability of the CR? Can > requip cause Dyskinesia? I know that in early-onset and early > detection only agonists are used in order to maximize the dopamine > still being produced by the brain. My heart is going out to my > friend. I told her I would be posing this to the list..Any > opinions, suggestions and Rph input would be very much appreciated. > > > Sandy Norris 40/28/20 > "Faith is the daring of the soul to go farther than it can see."