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You are close, Shirley, but not quite. All that happens is that you release the CR from the Sinemet and it just becomes a regular medication. CR means it is a controlled release, and it just dissolves more slowly in the digestive tract. Michel Shirley Anton wrote: > Sandy, there was something on the list recently (or maybe it was on the PD > Board in USA) that said definitely not to cut a Sinemet CR in half because it > disintegrates before it reaches the brain and therefore does no good at all.