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Yen, I am on Sinemet 10/100 mg and I have had Pd for 20 years. It is my experience that the generic does not do as well as the namebrand sinemet. Not everyone feels that way though. Your body may respond just as well to generic. Hope this helps.... Sandy Norris 40/28/20 "Faith is the daring of the soul to go farther than it can see."