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HI Just read your response to Marjorie..... I started Sinimet in 1992, started thyroid meds in 1995.......and the story is the same with both.....it depends on the person. I take trade name Sinimet for better results than generic. I use Levoxyl (generic for the Synthroid) for the thyroid......for better results. For some strange reason I have horrible headaches on the Synthroid, and not with the Levoxyl. Like Marjorie says, it does make a difference in the way we feel.....if your thyroid is not working well. Rita