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Charles, Can you tell us what specifically was studied and the results of the study? on 10/8/00 8:33 AM, Charles Williams at [log in to unmask] wrote: > I have heard this theory too, in UK. In fact I took part in research on > scans that is based on the idea that MSA and PD are associated with > inflammation, which may contribute to progression. Documentation mentioned > the possibility of anti-inflammatory drugs like aspirin being used for > treatment. > > -----Original Message----- > From: William P. Taggart <[log in to unmask]> > To: [log in to unmask] <[log in to unmask]> > Date: 08 October 2000 11:36 > Subject: Ibuprofen v Parkinson's > > > Ibuprofen may reduce the risk of Parkinson's and Alzheimer's <<...>> > > > Although non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen > have been found to reduce the risk of Alzheimer's disease (AD), the > underlying mechanisms of action are unknown. However, Casper and colleagues > have recently found that NSAIDs protect neurones from glutamate toxicity in > vitro - glutamate toxicity has been implicated in AD, Parkinson's disease > (PD), and other diseases. > Aspirin, acetaminophen, and ibuprofen were all found to attenuate the > reduction in dopamine uptake caused by glutamate on cultured primary rat > embryonic neurones taken from the mesencephalon area of the brain, > indicating preservation of neuronal integrity. Furthermore, ibuprofen 100µm > protected both dopaminergic neurones and neurones generally, against > glutamate toxicity. In addition, of the drugs tested, only ibuprofen > increased the relative number of dopaminergic neurons - by 47%. > The authors concluded that NSAIDs deserve further consideration as > neuroprotective agents in PD. > Source: Casper D et al. Neuroscience Letters 2000;289(3):201-204. Updated > September 2000. >