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Dear David, Sandy here in North Carolina. I have had pd for 20+ years and am now 40. Q? 1- Could you please describe to me what is "bad" in the way you experiance inner tremors? ANSWER: If I am getting close to the end of my dosage I get severe abdominal tremor. I have never taken Sinemet by a clock. My inner tremors tell me when it time for dosing. I get a sick kind of feeling. I feel the inner tremor through the stomach, bladder, and colon. Rigidity is also increased. Q? 2- Has Ldopa, or agonists much effect on inner tremors? (I'm not on any PD drugs) ANSWER: I am on Liquid Sinemet and Tasmar. The sinemet and tasmar does not take away the inner tremor...but if dosing time is "ONTIME" I can cope with the tremor better(It brings relief). The quicker I catch the inner tremor the better the response is to meds. Also, the severity of the inner tremor depends a lot on how much protein I have ingested that day. Q? 3- Have any of you had possitive results from the anti depressant drug "remeron" (spelling) and reduced tremors? ANSWER: Cannot help with Remeron. I am on Prozac. The Prozac is not for depression. It has been found that in my case, Prozac has been able to boost the effect of my Liquid Sinemet. I hope this helps! If you wish to ask anything further please feel free to e-mail me at [log in to unmask] . I hope this helps. Keep up the fight David...You are not alone.... Best of Luck, Sandy Norris 40/28/20 "Faith is the daring of the soul to go farther than it can see."