^^^^^^ WARM GREETINGS FROM ^^^^^^^^^^^^ :-) Ivan Suzman 50/39/36 [log in to unmask] :-) Portland, Maine land of lighthouses 46 rainy deg. F :-) ******************************************************************** --------- Forwarded message ---------- From: Ivan M Suzman <[log in to unmask]> To: [log in to unmask] Date: Wed, 18 Oct 2000 07:32:17 -0400 Subject: Re: JAMA: Pramipexole vs Levodopa as Initial Treatment for PD/Tasmar's role Message-ID: <[log in to unmask]> Dear Dr. Romero and PIEN friends, My pill-taking inner voice suggests to me that PWP's are better off (I am) if they use Sinemet or Atamet , or a generic brand of L-dopa, instead of pramipexole (otherwise known as Mirapex), in any stage of Parkinson's Disease. For me, Mirapex, or pramipexole, was way too strong, made me dizzy and mentally confused in even a tiny dose. It was scary. Meanwhile, L-dopa still works pretty well. I hope physicians can pay close attention to your summary. Meanwhile, what I wonder is, how do we get Tasmar elevated to proper respectability? It has been a great medication for me. I think its supposed links to changes in liver enzymes are only possible in rare cases, where physicians presecribed it in too high a dose, before they realized how to use it I use 300 mg per day (6 x 50 mg,). Each 50 mg dose is a 100 mg tablet, sliced in half. Jorge, thank you for sharing on the PIEN list. Incidentally, where do you practice? Any Tasmar experience? Thank you, Ivan Suzman, PWP 50/39/36 On Tue, 17 Oct 2000 20:33:45 -0500 Jorge A Romero MD <[log in to unmask]> writes: > This study is very significant: > > quality of life were BETTER in the Levo-dopa group than in the > pramipexole > group. > 2) The side effects of nausea, hallucinations, and sleepiness were > more > common in the pramipexole group than in the levodopa group. > 3) The PWP in the pramipexole group had fewer dyskinesias - BUT > DESPITE THE > FEWER DYSKINESIAS they reported better quality of life with > levodopa than > with pramipexole at the end of the study. >