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Hello Eveeryone, Thank you for the support while I try to figure out the lithium and cramps. To answer some questions brought up in your e-mail: My pharmacist said lithium is also used by people who have cramping after seizures. The Lancet June 14, 1986, page 1377, has a write up about Lithium and cramps with PD. Authors: Quinn and Marsden. It shows positive results from a study in London. It took from 1 day to 18 days for improvement using 600 - 1400 mg lithium, looks like they took it in a single dose at night. Just 600mg at one time made me feel ill. My pharmacist then said to take in divided doses. Anyway, after 6 days of increase in tremor and feeling ill, I probably won't be able to take this much longer, has not helped painful cramping/dystonia. I am starting to think I am drug intolerant. All agonist, anticholinergics, even selegiline make me ill and give me severe migraines. Levodopa was fine until I started having the dramatic and painful down times, now I am afraid of that because the side effects are far worse than the symptoms which were mainly tremor which went away when I walked or exercised. I feel there is little hope for me to resolve my current problems with drugs. This is my 6th yr diagnosed, 8 yrs with tremor, I am 52. What do people with PD do when they cannot take drugs? Thanks for all your support ........ Barbara