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Camilla our MDS said pretty much what Bob said. That it is an opiate and can cause addication and tolerance with long term use. George has not become addicted to it, however he is beginning to find it non affective. Our Drs have no idea what to do about his ongoing pain. from peripheral nueropathy. He has so many problems beside the PD that they together are trying to find solutions for all of his problems. None of our DRs say that it is contraindicated with Georges sinemet. In fact all have said it is not. Hugs Juanita CG for George 74/71/64