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> > i've understood that serotonin shortage is implicated in both cd and pd > is that your understanding too? I understand PWP can suffer from up to 40 per cent depletion in serotonin - a clear reason for depression. That said, serotonin is not purely linked to mood and there is increasing evidence that it plays a role in movement, too. There's a team in Manchester, UK, working on - and having success with - drugs which inhibit/excite serotonin to treat PD and dyskinesias. It was this group that proved that the sub-thalamic nucleus/globus pallidus pathway was glutaminergic - which led directly to the introduction of amantadine, the first non-dopaminergic drug for PD. Jemima