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On 23 Nov 2000, at 9:15, Parkinsons NZ Information Centre wrote: Has anyone heard of juvenile Parkinsonism? Is there any useful information, eg websites. I gather it's very rare, and affects children up to teens. Eva Petro ************* Hi Eva, I'll look it up for you..... I recall mention of juvenile parkinsonism on John Cottingham's site... DIFFERENTIAL DIAGNOSIS OF PARKINSON'S DISEASE AND THE PARKINSONISM PLUS SYNDROMES http://www.parkinsons-information-exchange-network-online.com/archive/091.html I've also seen this on NPF news referring to a group in Japan... First I searched the NPF site... 6 hits... http://www.parkinson.org/search.htm (search for juvenile) Parkinson Disease at an Early Age http://www.parkinson.org/earlypd.htm A type of Parkinson, Juvenile onset Parkinson, occurring in Japan, is associated with a mutant, and defective, parkin-gene on chromosome 6. http://www.parkinson.org/texthtms/talphasy.htm http://www.parkinson.org/alphasy.htm Understanding Proteins, Understanding Parkinson Disease http://www.parkinson.org/protein.htm More Mutations, More Light on Parkinson Disease http://www.parkinson.org/amino.htm Genetic Link in Most People with Young-Onset Parkinson Disease http://www.parkinson.org/genlink.htm Encarta Encyclopedia August 1999 - Parkinson Disease (1 brief reference to juvenile onset; interesting nonetheless) http://www.parkinson.org/encarta99.htm Next I searched Google for juvenile parkinson http://www.google.com/ (7000 hits...) An Equal Opportunity Disease Parkinson's disease doesn't just affect the old. The young also experience its far-reaching effects. By Abraham Lieberman, MD, and Juan Sanchez-Ramos, PhD, MD http://www.advanceforpa.com/pastarticles/sept4_00feature2.html NINDS - National Institute of Neurological Disorders and Stroke Parkinson's Disease Research Agenda Ruth L. Kirschstein, M.D. Acting Director, NIH - March 2000 Scroll down to: Using Genetics to Understand Parkinson’s Disease Molecular genetics is revolutionizing our understanding of human disease, even those diseases that are not inherited. Although mutations in the synuclein gene directly cause Parkinson’s disease in very few people, the discovery of those mutations led to new understanding of the critical role of synuclein in common Parkinson’s disease. Mutations and variability in the tau gene have been shown to underlie frontal-temporal dementia with parkinsonism and progressive supranuclear palsy, and mutations of the parkin gene have been shown to underlie juvenile parkinsonism, each also providing important clues to what causes neurons to die in common Parkinson’s disease. These known genes account for only a small proportion of inherited cases of Parkinson’s disease. Furthermore, interactions between complex genetic predisposition and environmental influences cause most cases of Parkinsonism. Clearly, major priorities must be to discover other gene defects that can cause or increase risk for Parkinson’s disease, to develop a more complete understanding of the role of these genes in parkinsonisms, and to use these genetic findings to make useful cellular and animal models of disease that would enable researchers to study the disease process and test new treatments. http://www.ninds.nih.gov/about_ninds/nihparkinsons_agenda.htm THE ROLE OF PARKIN AND RELATED PROTEINS IN PARKINSON’S DISEASE Release Date: April 24, 2000 http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-01-005.html Parkinson's Disease Issues in Caring for the Patient With Young-Onset Parkinson's Disease http://www.mmhc.com/hhcc/articles/HHCC9904/reese.html juvenile parkinson's vs. dopa responsive dystonia by wehseac22 (MSN) 6/13/00 12:01 AM Go to this site; then scroll down to Expand Message; click on Expand Message to read the whole thread... http://content.health.msn.com/message_board_message/668879 http://content.health.msn.com/message_board_message/672975 The density of the dopamine transporter enables dopa-responsive dystonia to be differentiated from juvenile Parkinson's disease http://www.parkinsonsdisease.com/news/N101_arc.HTM http://www.parkinsonsdisease.com/news/N101_arc.HTM#The density of the dopamine transporter Update on Parkinson's Disease - April 15 1999 ROSABEL YOUNG, M.D., M.S. http://www.aafp.org/afp/990415ap/2155.html Duke researchers find specific genetic link to broad spectrum of Parkinson's disease cases http://www.eurekalert.org/releases/dumc-drf100300.html Parkinson's Gene Mutation Found - by Mary Ann Swissler 3:00 a.m. Oct. 6, 2000 PDT http://www.wirednews.com/news/medtech/0,1286,39304,00.html Two cases of sporadic juvenile Parkinson's disease caused by homozygous deletion of Parkin gene http://lib.cpums.edu.cn/tsg/xxkd2005.html Autosomal recessive juvenile parkinsonism has been related to the long arm of chromosome 6 and to several genetic markers. http://scienceweek.com/swfr054.htm This is an edited transcript of a Spotlight Event originally presented May 24, 2000. Welcome to the Spotlight Auditorium for a chat on the latest advances in treatment for Parkinson's disease with Dr. Monique L. Giroux and Dr. Paul Spencer Fishman. Question: Until recently, with Michael J. Fox's diagnosis, I always thought of Parkinson's as an "old person's disease." Is this just an isolated case or is anybody at risk for Parkinson's? Dr. Giroux: Parkinson's disease was originally thought of as a disease that affected the elderly, but we now know it affects individuals of all age groups. Approximately 2 percent of the population over age 80 develop Parkinson's, and approximately 1 percent above the age of 60 develop the disease. However, individuals younger than 60 can also develop Parkinson's. In fact, even individuals as young as 5 or 6 can develop a form of Parkinson's disease called juvenile Parkinson's disease. http://wfubmc.drkoop.com/community/spotlight/transcripts/may2000/transcript-parkinsons- 000524.asp I hope this helps.... Best regards ...... murray *********************** [log in to unmask]