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Dear list, My name is Herb. I'm a PWP, 38 years old, about 1 year out from diagnosis. I've been reading the list for a few weeks now, and I've gotten quite a bit out of the discussion (although I've found it a challenge to keep up with the volume). I've been interested in the discussion on depression. Until diagnosed with PD, I had never felt depressed. Perhaps the closest I had felt was a reaction that I had to a drug I took once, prednisone. An hour or two after I took the pill, I had a very strong feeling that everything was wrong. This slowly developed into extreme nausea. Eventually I vomited and felt much better within minutes. Naturally, when I got my diagnosis, I had some things to deal with emotionally, like sadness, grief, etc. etc. At the same time, I began taking a dopamine agonist (Permax). Once I was up to a reasonable dose, the Permax did help a bit with mobility, however I began to have these feelings that things were not right. There was no real nausea, but it was reminiscent of the prednisone reaction. This was not the same as the sadness related to getting the diagnosis. I noticed that the feelings would come in waves, and that there would typically start one to two hours after the Permax dose. The bad feelings would also tend to get better a few hours after they came on. A friend of mine who is a pharmacologist told me about the "peak effect." Apparently , it is a known that when a drug is peaking in the bloodstream, there can often be a psychological effect like this. Anyway, in an attempt to stop the bad feelings, I decided to switch to Requip. My neurologist said that I could make the switch in one day. As soon as I stopped taking the Permax, the feelings pretty much went away. For a week or two I felt pretty good . But soon the feelings started to come back, and again they were timed in such a way that I could only suspect the drug. My understanding is that a dopamine agonist if anything should relieve depression, not cause it. Then again, I don't know that what I'm experiencing it is depression. At this point, I am only taking Requip. I have cut back slightly on the Requip, to five of the 2 mg tablets each day. I space them out so that I don't take two at one time, and that helps a little bit. Has anyone had a similar experience? Any thoughts? - Herb -- Herb Heinz [log in to unmask] For info on Herb's CD, "Failure": http://www.isproductions.com/herb/failure.shtml - For mp3 songs: http://www.mp3.com/herb For info on the new CD from Amy X Neuburg & Men, "Sports! Chips! Booty!": http://www.isproductions.com/amy/band.shtml