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[!!! = jmp] ---------------------------------------------------------------------------- Post: 088309 Date: 2000/10/28 Subj: WeMove: PD: Depression more significant than motor impairment - re-post ---------------------------------------------------------------------------- What contributes to quality of life in Parkinson's disease? Quality of life in Parkinson's disease (PD) is most strongly influenced by depression, according to this study, while motor impairment is not [!!!] a significant factor. 92 patients with PD were assessed with the: PDQ-39, Mini Mental State Exam, Schwab and England Scale, UPDRS motor scale, EQ-5D, and the Beck Depression Inventory. (available per URL below) http://www.geocities.com/janet313/wordspie/199710/032755.html Poorest scores on PDQ-39 were most strongly correlated with depression, as determined by the Beck Depression Inventory. Depression accounted for 54% of the quality of life score, while 10% was due to disability as determined by the Schwab and England scale. Additional contributing factors were postural instability and cognitive impairment, while motor impairment as determined by UPDRS correlated less strongly with quality of life. The authors conclude, "QoL in idiopathic Parkinson's disease is primarily determined by depression, disability, disease severity (particularly related to axial features), and cognitive impairment. "Patients with akinetic rigid subtype [!!!] have worse QoL than those with tremor dominant disease [!!!]. "The motor part of the UPDRS, although the primary outcome measure for clinical trials with antiparkinsonian medication, did not contribute significantly to QoL in Parkinson's disease, and additional emphasis on other disease features should therefore gain greater importance in the treatment of disease." A Schrag, M Jahanshahi, N Quinn J Neurol Neurosurg Psychiatry 2000;69:308-312 A related study concerning the EQ-5D in this patient sample is archived at http://www.wemove.org/emove/article.asp?ID=253 Editor: Richard Robinson ([log in to unmask]) Copyright 2000 WE MOVE http://www.wemove.org ---------------------------------------------------------------------------- janet paterson, an akinetic rigid subtype parkie 53 now /44 dx cd / 43 onset cd /41 dx pd / 37 onset pd TEL: 613 256 8340 SMAIL: POBox 171 Almonte Ontario K0A 1A0 Canada EMAIL: [log in to unmask] URL: http://www.geocities.com/janet313/