thanks Bob:
bob armentrout wrote:
>
> Maker of Diazinon to Phase Out Insecticide
>
>
<<big snip>>
>
> Syngenta AG is a large global agribusiness with
> 20,000 employees in 50 countries and headquarters in
> Basel, Switzerland. It was formed in November 2000
> from the agribusiness branch of Novartis and the
> agrochemical businesses of AstraZeneca.
Novartis is a big pharmeceutical manufatcurer also.
--------------------------------------------------------------------------------
-- i went to pub-med and searched on "diazinon" --
524 hits
got 200 text abstracts
downloaded to a text file
it has made for some interesting reading
and there is a long way to go...
here is a one example:
67: Arch Neurol 1999 Jan;56(1):90-4
Multiple system atrophy: the putative causative role of environmental toxins.
Hanna PA, Jankovic J, Kirkpatrick JB
Department of Neurology, Parkinson's Disease Center and Movement Disorders
Clinic, Baylor College of Medicine, Houston, Tex 77030, USA.
BACKGROUND: Whereas a number of studies have investigated the putative role of
environmental toxins in the pathogenesis of idiopathic Parkinson disease, the
possibility of such a role in multiple system atrophy has received little
attention. DESIGN AND SETTING: Review of records of patients examined in the
Parkinson's Disease Center and Movement Disorder Clinic, Baylor College of
Medicine, Houston, Tex, from July 1, 1977, to February 4, 1998. PATIENTS: We
reviewed 100 consecutive medical records of patients who satisfied the
diagnostic criteria for multiple system atrophy formulated by the Consensus
Committee of the American Autonomic Society and the American Academy of
Neurology. INTERVENTION: The type and amount of toxin exposure were
verified by
history and examination of records whenever possible. Severity of parkinsonism
was assessed by clinical rating scales. MAIN OUTCOME MEASURE: Development of
multiple system atrophy after environmental toxin exposure. RESULTS: Eleven
patients had a notable history of heavy exposure to environmental toxins. One
patient with multiple system atrophy confirmed by postmortem evaluation was
exposed to high concentrations of malathion, diazinon, and formaldehyde, while
the other patients with multiple system atrophy had well-documented high
exposures to agents including n-hexane, benzene, methyl isobutyl ketone, and
pesticides. The case studied pathologically demonstrated extensive advanced
glial changes, including glial cytoplasmic inclusions in deep cerebellar white
matter, brainstem, cortex (superior frontal, insula) and putamen, with notable
cell loss and depigmentation of the substantia nigra and locus ceruleus.
CONCLUSION: While many studies report a possible role of environmental
toxins in
Parkinson disease, such a role is even more likely in multiple system atrophy,
as this is a sporadic disease.
Publication Types:
Review
Review of reported cases
PMID: 9923766, UI: 99120641
Ray Strand
Prairie Sky Design
-------------( on the Edge of the Prairie Abyss )---------------
when the sky is clear
the ground is visible
48/dx PD 2 yrs/40? onset/retired
