IKathelyn, I take 1/2 of the fast acting SInemet 25/100 - albeit I do not chew it - around 6:30. Then I go and have some Cereal with milk. Then around 7 AM I take: 25/100 SInemet CR - ELDEPRYL 5MG - Ziac ( BP ) and LIPITOR 11/2 MG of MIRAPEX. about 1 hour later I am down in the dumps - I suspect that the combination of pills is doing something - maybe? Except for the ELdepryl and LIPITOR and ZIAC, I repeat the same dosage every 4 hours - that is the limit - If I don't, i am worthles for the next hour. I have told my Neuro that MIRAPEX does not do anything for me, proof is that I ake two Sinemets CR by themselves and that gets me by until about 4 AM. OH Yes, I started to take one before I go to sleep, othewise if I have to get up I will be a little more mobile. Lately I have noticed it more than ever. Perhaps I am in transition to the next stage? I have also asked myself if I may not be getting dehydrated in the morning, you know, after you go to the bathroom. At any rate, you wanted more info, so I gave it to you. Thanks a lot, Mario 54/49