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Hello Ally, Sinemet is a potent drug in helping combat PD. I myself take it, it depends of course on your Neuro as to dosage etceteras. I myself find it to be better than Madopar which I took for a number of years. With sinemet one must stick strictly to the times and dosages preascribed by the Neuro. If you think that it is loosing it effectiveness then as I say apply again to your Neuro. Once a year seems very little to see him. I myself go every three months. Keep your chin up there are other drugs becoming available. Bern...............Peace [log in to unmask] http://members.chello.at/bernard.shaw/poetry.html