> G'day again from the Siren City of the South Pacific(Sydney,of >course). I have been suffering frequently recently that horribly >amorphous internal tremor and I was hoping to receive/exchange info about >this blight on sleep.Only this morning I visited my neuro and he seems >rather bemused by it.I would be deeply grateful for any info.I would be >delighted to help in any way I can in return. Address -- >[log in to unmask] PS A big thank you to the people who contacted me on >Remeron/mirtazapine. Hi Tom--- In his long post re: secondary symptoms, J.R.Bruman notes the following, and mentions internal tremor. : EXTERNAL MOVEMENT PROBLEMS (cont.) 3 TREMOR: A rhythmic reciprocating motion which may or may not be noticed, or voluntarily suppressed, by the PWP. All tremors result from failure of the feedback loop, that is, imbalance or mis-timing between a signal that tells a muscle to act and the corresponding signal that tells it when to stop. In engineering terms, the system oscillates. Some PWP report internal tremors in various parts of the body. Tremor is one of the 3 cardinal symptoms of PD, evidently arising from a defect in supply or employment of dopamine. It often abates or disappears under therapy, either medicinal or surgical. Tremor of a different kind also appears in dyskinesia, to be discussed later, resulting from an excess of dopamine. When disabling tremor is of primary concern and does not respond to drug therapy, surgery is a last resort. Since tremor seems to originate in the thalamus, or more precisely the subthalamic nucleus, that is the site of choice for the electrode, either for ablation (destruction) or for chronic deep-brain stimulation. ******* I suggest you could also put your question to the "Ask Dr. Lieberman" section of the NPF website: >http://www.parkinson.org/. You need to "join" but it's free and easy. >Peter has also spoken oif this tremor --rarely-- but he doesn;t have much >external tremor either. Good luck! Camilla Flintermann, CG for Peter 82/70/55 Oxford, Ohio <[log in to unmask]> on the web at http://members.tripod.lycos.nl/genugten/flinterm.htm and also at http://www.geocities.com/camillahf/index.html "Ask me about the CARE list for Caregivers of Parkinsonians ! " And visit the CARE webring at http://www.crosswinds.net/~caregivers/index.html