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Agony and ecstasy: a review of MDMA effects and toxicity. BACKGROUND: Ecstasy is a recreational drug with an anecdotal reputation for safety. However, reports of adverse effects and fatalities have increased in the medical and popular press. METHOD: Literature search and review. RESULTS: Acute Ecstasy toxicity does not appear to be due to overdose and cannot be solely attributed to the nature of the usual ambient environment. Adverse effects include hyperthermia, seizures, cardiac arrhythmias, hepatotoxicity, hyponatraemia and many psychiatric disorders. Ecstasy causes serotonergic neurotoxicity in the brains of animals at doses close to those used by humans, but its long-term effect on the human brain is unknown. CONCLUSION: Ecstasy toxicity should be considered in the differential diagnosis of a variety of medical and psychiatric conditions. Given its popularity, both the acute and the potential long-term effects are a cause for concern. Eur Psychiatry 2000 Aug;15(5):287-94 Burgess C, O'Donohoe A, Gill M Department of Psychiatry, The Trinity Health Sciences Centre, St. James's Hospital, Dublin 8, Ireland. PMID: 10954872 http://www.ncbi.nlm.nih.gov/PubMed/ janet paterson, an akinetic rigid subtype parkie 53 now / 44 dx cd / 43 onset cd / 41 dx pd / 37 onset pd TEL: 613 256 8340 SMAIL: PO Box 171 Almonte Ontario K0A 1A0 Canada EMAIL: [log in to unmask] URL: http://www.geocities.com/janet313/