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Mary, I am a 59 year old retired pharmacist who has had PD for 23 years. I have several friends who are taking Comtan. The COMT enzyme may interfere with the levodopa during its transport from the intestines to the brain. It breaks the lovodopa down into an ineffective product. Comtan prevents this from happening. Only one friend had to discontinue it because he was getting severe dyskinesia. The others did notice dyskinesia but lowering the daily intake of Sinemet took care of the problem.. I feel it is a very good medication if the Sinemet is starting to fail you a bit. You are taking Sinemet, aren't you? Dave Purdy, R.Ph. Mary Legan wrote: > Would you please tell me the state & reputation of COMPT INHIBITORS lately. > I haven't kept up with this, and it is important to me. thank you. > > MDawn