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For some patients Comtan may work. For others all it does is produce orange urine. My brother has used both. Comtan was absolutely useless. Tasmar works great and is well worth the inconvenience of a blood test every two weeks. Steve took Tasmar before and after his bi-STN in 1998. He quit when it was recalled and things went progressively downhill. Tried Comtan with absolutely no result. Went back to Tasmar and got immediate benefit. It all depends on the patient. Paul ----- Original Message ----- From: dpurdy <[log in to unmask]> To: <[log in to unmask]> Sent: Monday, February 19, 2001 5:27 AM Subject: Re: COMPT INHIBITORS - help Mary, I am a 59 year old retired pharmacist who has had PD for 23 years. I have several friends who are taking Comtan. The COMT enzyme may interfere with the levodopa during its transport from the intestines to the brain. It breaks the lovodopa down into an ineffective product. Comtan prevents this from happening. Only one friend had to discontinue it because he was getting severe dyskinesia. The others did notice dyskinesia but lowering the daily intake of Sinemet took care of the problem.. I feel it is a very good medication if the Sinemet is starting to fail you a bit. You are taking Sinemet, aren't you? Dave Purdy, R.Ph. Mary Legan wrote: