Dave- how is the Sinemet 25/100 and sinemet 25/100 CR different? I know the latter stays in your system longer but how does it work and why would they use the Cr instead? I was switched today from sinemet 25/100 to the 25/100 CR do they react or should i expect anything different? Thanks Diane ----- Original Message ----- From: dpurdy <[log in to unmask]> To: <[log in to unmask]> Sent: Tuesday, February 27, 2001 6:19 AM Subject: Re: ?Too much Sinemet > Mary, > The 10/100 has the same amt of levodopa. The carbidopa is less. The carbidopa is > being used to help the levodopa from being destroyed by enzymes and also to help > prevent nausea. It is felt that about 75mg per day is recommended. Excess > levodopa would probably result in dyskinesia (abnormal body movements such as > twisting etc.) You might want to discuss with the doctor that you want to > experiment with the dosage a little. Perhaps splitting your levodopa in half and > taking it a little closer together might be a wise suggestion. Please let me know > your thoughts. > > Dave Purdy, retired R.Ph. & Parkinsonian > > Mary Legan wrote: > > > Please would you answer fast? What are the signs & symptoms of too much > > Sinemet? I've got to get my neuro to put me back to 10/100. She has now put > > me on 25/100. With new psychiatric meds, too, I need someone to help me > > Identify the signs & symptoms of too much sinemet so I can at least get her > > to go back to what I know was better for me. She has many gatekeepers, & I > > will just be told to stay on what she said. The thing is, because I had so > > many left, I stayed on it way past when she knew about it. I just started > > the 25/100 about 3 weeks ago, and am so uncomfortable. Please tell me the > > signs & symptoms so I can articulate quickly what is happening. Would you > > send this quickly, if possible? > > > > MDawn30475805