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Diane, They both have the same total amount of each drug. However, the 25-100 plain one is released all at one time and wears off relatively quickly...probably gone within at least 3 hours. On the other hand, the 25/100 CR has a smaller portion of it released in the beginning and the rest gradually broken down over perhaps 6 hours or less. Why did they change it? Were you needing it soon after the dose was taken? Was it not lasting very long? Personally, I can't take the CR. I get dyskinetic and it lasts for a long time. I take permax and Sinemet together...1/2 of each of them every 1 1/2 hours. That dosage has been ideal for me. You will just have to try the CR and see how it does. Give a fair chance to derive full benefits then make you decision as to the best of the two. You may have head that Sinemet doesn't work after 8 yrs or so. Well, I've been on it since 1984 (18 years) and it is still going fine. Good luck...mayyou have some great days ahead. Dave DIANE/GREG NICOLAOU wrote: > Dave- how is the Sinemet 25/100 and sinemet 25/100 CR different? I know the > latter stays in your system longer but how does it work and why would they > use the Cr instead? > > I was switched today from sinemet 25/100 to the 25/100 CR do they react or > should i expect anything different? Thanks Diane > ----- Original Message ----- > From: dpurdy <[log in to unmask]> > To: <[log in to unmask]> > Sent: Tuesday, February 27, 2001 6:19 AM > Subject: Re: ?Too much Sinemet > > > Mary, > > The 10/100 has the same amt of levodopa. The carbidopa is less. The > carbidopa is > > being used to help the levodopa from being destroyed by enzymes and also > to help > > prevent nausea. It is felt that about 75mg per day is recommended. Excess > > levodopa would probably result in dyskinesia (abnormal body movements such > as > > twisting etc.) You might want to discuss with the doctor that you want to > > experiment with the dosage a little. Perhaps splitting your levodopa in > half and > > taking it a little closer together might be a wise suggestion. Please let > me know > > your thoughts. > > > > Dave Purdy, retired R.Ph. & Parkinsonian > > > > Mary Legan wrote: > > > > > Please would you answer fast? What are the signs & symptoms of too much > > > Sinemet? I've got to get my neuro to put me back to 10/100. She has > now put > > > me on 25/100. With new psychiatric meds, too, I need someone to help me > > > Identify the signs & symptoms of too much sinemet so I can at least get > her > > > to go back to what I know was better for me. She has many gatekeepers, > & I > > > will just be told to stay on what she said. The thing is, because I had > so > > > many left, I stayed on it way past when she knew about it. I just > started > > > the 25/100 about 3 weeks ago, and am so uncomfortable. Please tell me > the > > > signs & symptoms so I can articulate quickly what is happening. Would > you > > > send this quickly, if possible? > > > > > > MDawn30475805