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Helllo, My name is Cricket, I have pd. for 17yrs. & I am 54yrs. My Doctor took me off CR. because of many movments, but know since I change to regular, my drugs wear off every 2hrs. or so. I have trouble walking then, I feeze. I started taking Symmetrel for the extra movements & it has help alot. My question is should I got back to the CR or just take my sinimet closer together. Right now I take my medications every 3 hrs. & of course they are all different drug throught out the day. Thank you dpurdy wrote: > Diane, > They both have the same total amount of each drug. However, the 25-100 plain one > is released all at one time and wears off relatively quickly...probably gone > within at least 3 hours. On the other hand, the 25/100 CR has a smaller portion > of it released in the beginning and the rest gradually broken down over perhaps > 6 hours or less. Why did they change it? Were you needing it soon after the > dose was taken? Was it not lasting very long? Personally, I can't take the CR. I > get dyskinetic and it lasts for a long time. I take permax and Sinemet > together...1/2 of each of them every 1 1/2 hours. That dosage has been ideal for > me. You will just have to try the CR and see how it does. Give a fair chance to > derive full benefits then make you decision as to the best of the two. You may > have head that Sinemet doesn't work after 8 yrs or so. Well, I've been on it > since 1984 (18 years) and it is still going fine. Good luck...mayyou have some > great days ahead. > Dave > > DIANE/GREG NICOLAOU wrote: > > > Dave- how is the Sinemet 25/100 and sinemet 25/100 CR different? I know the > > latter stays in your system longer but how does it work and why would they > > use the Cr instead? > > > > I was switched today from sinemet 25/100 to the 25/100 CR do they react or > > should i expect anything different? Thanks Diane > > ----- Original Message ----- > > From: dpurdy <[log in to unmask]> > > To: <[log in to unmask]> > > Sent: Tuesday, February 27, 2001 6:19 AM > > Subject: Re: ?Too much Sinemet > > > > > Mary, > > > The 10/100 has the same amt of levodopa. The carbidopa is less. The > > carbidopa is > > > being used to help the levodopa from being destroyed by enzymes and also > > to help > > > prevent nausea. It is felt that about 75mg per day is recommended. Excess > > > levodopa would probably result in dyskinesia (abnormal body movements such > > as > > > twisting etc.) You might want to discuss with the doctor that you want to > > > experiment with the dosage a little. Perhaps splitting your levodopa in > > half and > > > taking it a little closer together might be a wise suggestion. Please let > > me know > > > your thoughts. > > > > > > Dave Purdy, retired R.Ph. & Parkinsonian > > > > > > Mary Legan wrote: > > > > > > > Please would you answer fast? What are the signs & symptoms of too much > > > > Sinemet? I've got to get my neuro to put me back to 10/100. She has > > now put > > > > me on 25/100. With new psychiatric meds, too, I need someone to help me > > > > Identify the signs & symptoms of too much sinemet so I can at least get > > her > > > > to go back to what I know was better for me. She has many gatekeepers, > > & I > > > > will just be told to stay on what she said. The thing is, because I had > > so > > > > many left, I stayed on it way past when she knew about it. I just > > started > > > > the 25/100 about 3 weeks ago, and am so uncomfortable. Please tell me > > the > > > > signs & symptoms so I can articulate quickly what is happening. Would > > you > > > > send this quickly, if possible? > > > > > > > > MDawn30475805