Hi-- I may not be understanding your problem--but you are getting the same amount of Levodopa (100mg) with both the 25/100 and the 10/100. If the 25/100 is the CR you mentioned, then it will last longer in your system. I'm not sure why the "readjustment" should take several weeks--but as everyone is different I really would suggest bugging your neuro till you get answers---that is the best place to get such specific dosage advice. >I'm mixed up with several meds, but for now will focus on Sinemet. My neuro >was prescribing 25/100, but I was taking 10/100 as I had many left. Then I >ran out & started the 25/100. I discovered after 3 wks or so when it kicked >in that it was way too high for me. Now I have the 10/100 again, but it will >take a couple weeks to readjust. So I am trying to keep it low during the >day. I have one 1/100 left after 7:00, and a Sinemet CR. Will you please >tell me if & when I should take the CR? Or if & when I should take the last >regular Sinemet 10/100? It's more complex because of some psychiatric med >changes, but I won't talk about that now so I hopefully might get a fast >answer on the Sinemet issue. Please help quickly! > >M.Dawn Camilla Flintermann, CG for Peter 82/70/55 Oxford, Ohio <[log in to unmask]> on the web at http://members.tripod.lycos.nl/genugten/flinterm.htm and also at http://www.geocities.com/camillahf/index.html "Ask me about the CARE list for Caregivers of Parkinsonians ! " And visit the CARE webring at http://www.crosswinds.net/~caregivers/index.html