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Dave, Thanks for your reply about the Sinemet differences. We are very lucky to have knowlegable professional people such as yourself on here. Dr.took me off the regular sinemet and switched me to the CR because the other was wearing off between doses (I've only been on the sinemet for two weeks) and i've only taken the CR for two days now but it seems to be working ok. I just wish i didn't have the nightmares all night. Is that from the drug or P.D. or both? Also I have another question for you - I hear and read that there are drugs we should definately NOT take with PD while on sinemet can you tell me what they are (I'Ve heard Demerol is one). I was on Covera HS (Verapimil) 240 mg largest dose-for hypertension went on sinemet started feeling light-headed and dizzy at times, checked my BP (I work for a large cardiology group) and it was very low-then I read in PDR hypertensive meds should be adjusted BEFORE starting Sinemet so i called my family doc who took me off the Covera completely and my BP has remained just fine since. Must be the neurologist overlooked that. I am a cardiac ultrasound technician and can tell you lots about the heart but very little about the brain although i"m learning fast and many thanks to all of you for your help. Diane ( Original Message ----- From: dpurdy <[log in to unmask]> To: <[log in to unmask]> Sent: Tuesday, February 27, 2001 9:52 AM Subject: Re: ?Too much Sinemet > Diane, > They both have the same total amount of each drug. However, the 25-100 plain one > is released all at one time and wears off relatively quickly...probably gone > within at least 3 hours. On the other hand, the 25/100 CR has a smaller portion > of it released in the beginning and the rest gradually broken down over perhaps > 6 hours or less. Why did they change it? Were you needing it soon after the > dose was taken? Was it not lasting very long? Personally, I can't take the CR. I > get dyskinetic and it lasts for a long time. I take permax and Sinemet > together...1/2 of each of them every 1 1/2 hours. That dosage has been ideal for > me. You will just have to try the CR and see how it does. Give a fair chance to > derive full benefits then make you decision as to the best of the two. You may > have head that Sinemet doesn't work after 8 yrs or so. Well, I've been on it > since 1984 (18 years) and it is still going fine. Good luck...mayyou have some > great days ahead. > Dave > > DIANE/GREG NICOLAOU wrote: > > > Dave- how is the Sinemet 25/100 and sinemet 25/100 CR different? I know the > > latter stays in your system longer but how does it work and why would they > > use the Cr instead? > > > > I was switched today from sinemet 25/100 to the 25/100 CR do they react or > > should i expect anything different? Thanks Diane > > ----- Original Message ----- > > From: dpurdy <[log in to unmask]> > > To: <[log in to unmask]> > > Sent: Tuesday, February 27, 2001 6:19 AM > > Subject: Re: ?Too much Sinemet > > > > > Mary, > > > The 10/100 has the same amt of levodopa. The carbidopa is less. The > > carbidopa is > > > being used to help the levodopa from being destroyed by enzymes and also > > to help > > > prevent nausea. It is felt that about 75mg per day is recommended. Excess > > > levodopa would probably result in dyskinesia (abnormal body movements such > > as > > > twisting etc.) You might want to discuss with the doctor that you want to > > > experiment with the dosage a little. Perhaps splitting your levodopa in > > half and > > > taking it a little closer together might be a wise suggestion. Please let > > me know > > > your thoughts. > > > > > > Dave Purdy, retired R.Ph. & Parkinsonian > > > > > > Mary Legan wrote: > > > > > > > Please would you answer fast? What are the signs & symptoms of too much > > > > Sinemet? I've got to get my neuro to put me back to 10/100. She has > > now put > > > > me on 25/100. With new psychiatric meds, too, I need someone to help me > > > > Identify the signs & symptoms of too much sinemet so I can at least get > > her > > > > to go back to what I know was better for me. She has many gatekeepers, > > & I > > > > will just be told to stay on what she said. The thing is, because I had > > so > > > > many left, I stayed on it way past when she knew about it. I just > > started > > > > the 25/100 about 3 weeks ago, and am so uncomfortable. Please tell me > > the > > > > signs & symptoms so I can articulate quickly what is happening. Would > > you > > > > send this quickly, if possible? > > > > > > > > MDawn30475805