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Diane, You should avoid taking anti-psychotic, Reglan, Compazine (both anti-vomiting drugs), and Benadryl unless prescribed by your neurologist. All these drugs may exacerbate the symptoms. Demerol is no problem unless you are taking Eldepryl (selegiline, deprenyl). DIANE/GREG NICOLAOU wrote: > Dave, > > Thanks for your reply about the Sinemet differences. We are very lucky to > have knowlegable professional people such as yourself on here. > > Dr.took me off the regular sinemet and switched me to the CR because the > other was wearing off between doses (I've only been on the sinemet for two > weeks) and i've only taken the CR for two days now but it seems to be > working ok. I just wish i didn't have the nightmares all night. Is that > from the drug or P.D. or both? > > Also I have another question for you - I hear and read that there are drugs > we should definately NOT take with PD while on sinemet can you tell me what > they are (I'Ve heard Demerol is one). I was on Covera HS (Verapimil) 240 mg > largest dose-for hypertension went on sinemet started feeling light-headed > and dizzy at times, checked my BP (I work for a large cardiology group) and > it was very low-then I read in PDR hypertensive meds should be adjusted > BEFORE starting Sinemet so i called my family doc who took me off the Covera > completely and my BP has remained just fine since. Must be the neurologist > overlooked that. I am a cardiac ultrasound technician and can tell you lots > about the heart but very little about the brain although i"m learning fast > and many thanks to all of you for your help. Diane > ( Original Message ----- > From: dpurdy <[log in to unmask]> > To: <[log in to unmask]> > Sent: Tuesday, February 27, 2001 9:52 AM > Subject: Re: ?Too much Sinemet > > > Diane, > > They both have the same total amount of each drug. However, the 25-100 > plain one > > is released all at one time and wears off relatively quickly...probably > gone > > within at least 3 hours. On the other hand, the 25/100 CR has a smaller > portion > > of it released in the beginning and the rest gradually broken down over > perhaps > > 6 hours or less. Why did they change it? Were you needing it soon after > the > > dose was taken? Was it not lasting very long? Personally, I can't take the > CR. I > > get dyskinetic and it lasts for a long time. I take permax and Sinemet > > together...1/2 of each of them every 1 1/2 hours. That dosage has been > ideal for > > me. You will just have to try the CR and see how it does. Give a fair > chance to > > derive full benefits then make you decision as to the best of the two. You > may > > have head that Sinemet doesn't work after 8 yrs or so. Well, I've been on > it > > since 1984 (18 years) and it is still going fine. Good luck...mayyou have > some > > great days ahead. > > Dave > > > > DIANE/GREG NICOLAOU wrote: > > > > > Dave- how is the Sinemet 25/100 and sinemet 25/100 CR different? I know > the > > > latter stays in your system longer but how does it work and why would > they > > > use the Cr instead? > > > > > > I was switched today from sinemet 25/100 to the 25/100 CR do they react > or > > > should i expect anything different? Thanks Diane > > > ----- Original Message ----- > > > From: dpurdy <[log in to unmask]> > > > To: <[log in to unmask]> > > > Sent: Tuesday, February 27, 2001 6:19 AM > > > Subject: Re: ?Too much Sinemet > > > > > > > Mary, > > > > The 10/100 has the same amt of levodopa. The carbidopa is less. The > > > carbidopa is > > > > being used to help the levodopa from being destroyed by enzymes and > also > > > to help > > > > prevent nausea. It is felt that about 75mg per day is recommended. > Excess > > > > levodopa would probably result in dyskinesia (abnormal body movements > such > > > as > > > > twisting etc.) You might want to discuss with the doctor that you want > to > > > > experiment with the dosage a little. Perhaps splitting your levodopa > in > > > half and > > > > taking it a little closer together might be a wise suggestion. Please > let > > > me know > > > > your thoughts. > > > > > > > > Dave Purdy, retired R.Ph. & Parkinsonian > > > > > > > > Mary Legan wrote: > > > > > > > > > Please would you answer fast? What are the signs & symptoms of too > much > > > > > Sinemet? I've got to get my neuro to put me back to 10/100. She > has > > > now put > > > > > me on 25/100. With new psychiatric meds, too, I need someone to > help me > > > > > Identify the signs & symptoms of too much sinemet so I can at least > get > > > her > > > > > to go back to what I know was better for me. She has many > gatekeepers, > > > & I > > > > > will just be told to stay on what she said. The thing is, because I > had > > > so > > > > > many left, I stayed on it way past when she knew about it. I just > > > started > > > > > the 25/100 about 3 weeks ago, and am so uncomfortable. Please tell > me > > > the > > > > > signs & symptoms so I can articulate quickly what is happening. > Would > > > you > > > > > send this quickly, if possible? > > > > > > > > > > MDawn30475805