Try getting off the CR (I experienced the same thing), go to 10/100's. Limit carbidopa (that's the 10 part) to 70-100mg per day. This made a big difference for me. I also added Amantadine. I think you are overmedicated.... Strickly, my opinion and experience - I could be wrong. Burdette. PD 17 yrs/DX at 35 -----Original Message----- From: Mario A. Gonzalez <[log in to unmask]> To: [log in to unmask] <[log in to unmask]> Date: Sunday, March 04, 2001 4:41 PM Subject: What happens at 2:30?> I take the following dosages: 6:30 - One half Sinemet 25/100 Regular 7:00 - .75 Mirapex - 1 25/100 Sinemet CR 10:30- One half Sinemet 25/100 Regular 11:00 - 1 25/100 Sinemet CR 1:00 - .75 Mirapex 2:30 - One half Sinemet 25/100 3:00 - 1 25/100 Sinemet CR Problem: When I take the 2:30 Yellow 25/100 SInemet regular, I have been noticing a pattern: I become completely wasted. This could last from 30 minutes to 1hour or it can go on until the 6:30 dosage and beyond. Am I being under/overmedicated? Is that 1:00 Mirapex doing me no good? Do I need more? What have been your experiences? Appreciate any help you can offer . Mario