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Try getting off the CR (I experienced the same thing), go to 10/100's.  Limit carbidopa (that's the 10 part) to 70-100mg per day.  This made a big difference for me.  I also added Amantadine.  I think you are overmedicated....
 
Strickly, my opinion and experience - I could be wrong.
Burdette.
PD 17 yrs/DX at 35
-----Original Message-----
From: Mario A. Gonzalez <[log in to unmask]>
To: [log in to unmask] <[log in to unmask]>
Date: Sunday, March 04, 2001 4:41 PM
Subject: What happens at 2:30?>

  I take the following dosages:
    6:30 - One half Sinemet 25/100   Regular
    7:00 - .75 Mirapex - 1 25/100 Sinemet CR 
   10:30- One half Sinemet 25/100  Regular
  11:00 - 1 25/100 Sinemet CR       
    1:00 - .75 Mirapex
    2:30 - One half Sinemet 25/100
    3:00 - 1 25/100 Sinemet CR  
 
Problem:
 
When I take the 2:30 Yellow 25/100 SInemet regular, I have been noticing a pattern: I become completely wasted.
This could last from 30 minutes to 1hour or it can go on until the 6:30 dosage and beyond.
Am I being under/overmedicated?
Is that 1:00 Mirapex doing me no good?
Do I need more?
 
What have been your experiences?
Appreciate any help you can offer .
 
Mario