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Apomorphine is used for many years in many countries in Europe. The drug is available and not experimental in Europe. It is being used for two reasons: 1. by some neurologists it is used as a diagnostic tool. A positive response of the drug on the symptoms of PD is in favor of the diagnosis of idiopathic Parkinso'n's disease. 2. In later stage disease it is used to acutely treat freezing episodes. It can only be given subcutanouesly using a needle. It has side effects just like one sees with levodopa and the duration of the response is very short. Only by using a apomorphine pump one can obtain longlasting effect,but dyskinesias will not subside. It will eventually cause skin problems as well. In countries where DBS is not available or only limited to a small number, it is frequently used (England, The Netherlands). Chris van der Linden, M.D. ----- Original Message ----- From: "Michel Margosis" <[log in to unmask]> To: <[log in to unmask]> Sent: Tuesday, March 20, 2001 9:46 PM Subject: Re: Clinical trials > I understand it is commonly used in France and other > countries in Europe. > Michel > > ----- Original Message ----- > From: "EJB" <[log in to unmask]> > To: <[log in to unmask]> > Sent: Tuesday, March 20, 2001 11:05 AM > Subject: Clinical trials > > > > Hello to all- I have signed up for an investigational cliinical trial for > an injectable drug to adress the "on-off" syndrome associated with the > long term use of sinemet. The drug is apomorphine. I have researched the > web and found out a lot, but has anyone had personal experience with this > medication? The injections are given sub-cutaneously by the patient. Thanks > in advance for your responses. > > > > E.J. Bryan > > "I never said the things I said"--Yogi Berra > > 52/40/13 > > > > [log in to unmask] > > > > ---------------------------------------------------------------------- > > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > > In the body of the message put: signoff parkinsn > > > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn